Figure 1.
Three differential diagnoses of the acute/subacute course of RA-ILD are acute exacerbation of RA-ILD, drug-induced pneumonitis, and PCP. Abbreviations: DAD = diffuse alveolar damage; MTX = methotrexate; PCP = Pneumocystis pneumonia; RA-ILD = rheumatoid arthritis-associated interstitial lung disease; TMP/SMX = trimethoprim/sulfamethoxazole. Flow chart. First *, if the possibility of drug-induced pneumonitis exists, the drugs treating RA should be stopped promptly. Second, clinicians should judge severity ** and the possibility of DAD ***. Three differential diagnoses of the acute/subacute course of RA-ILD are acute exacerbation of RA-ILD, drug-induced pneumonitis, and PCP.