Figure 9.

Transbronchial lung cryobiopsy in a case of RA-ILD (73-year-old woman). (A) Chest CT shows subpleural reticulations with honeycombing as the component of UIP in the lower lung. Lung cryobiopsy was performed in the right B9 (dashed square). (B) Hematoxylin and eosin staining show the lesion to be characterized by dense collagenous fibrosis with architectural destruction as a UIP pattern along with inflammatory cells including LF in the interstitial tissue. (B’) A high-power magnification view of the dashed square in (B) shows a mild inflammatory change. (C) Elastica van Gieson staining shows the lesion as in (B). Abbreviations: RA = rheumatoid arthritis; ILD = interstitial lung disease; CT = computed tomography; UIP = usual interstitial pneumonia; LF = lymphoid follicle.