Figure 4.

Representative images of p-Tau (S396) staining in WT mouse dentate gyrus area 1 month or 4 months following intra-hippocampal injections of NDEVs enriched from plasma from a control case (A,B) and a DS-AD case (C,D). Note the significant increase in p-Tau inclusions in neurons after DS-AD NDEV injections (arrowheads in (C,D)), especially in neurons located in the granule cell layer (GCL). Few, if any, intraneuronal p-Tau inclusions were observed in brains injected with control NDEVs (A,B). Scale bar in (D) represents 100 μm.