Table 1.
Investigated parameters in the subgroups divided according to phenotypes of PCOS.
| Parameters | Phenotype 1 n = 363 |
Phenotype 2 n = 73 |
Phenotype 3 n = 73 |
Phenotype 4 n = 97 |
p Value |
|---|---|---|---|---|---|
| Age (years) | 24.0 (22.0–28.0) | 27.0 (23.0–33.0) | 25.0 (22.0–28.5) | 25.0 (22.0–29.0) | >0.05 |
| BMI (kg/m2) | 24.0 (21.0–30.1) | 22.8 (19.6–27.1) | 22.4 (19.8–26.5) | 22.9 (20.4–27.2) | 0.016 |
| WHR | 0.8 (0.8–0.9) | 0.8 (0.8–0.9) | 0.8 (0.8–0.9) | 0.8 (0.8–0.9) | 0.017 |
| CHO (mg/dL) | 177.0 (160.0–197.0) | 176.0 (161.0–201.0) | 167.5 (153.0–194.0) | 179.0 (158.0–197.0) | >0.05 |
| HDL-C (mg/dL) | 51.2 ± 12.2 | 56.5 ± 11.9 | 57.4 ± 10.2 | 55.7 ± 11.3 | 0.001 |
| LDL-C (mg/dL) | 104.0 (90.0–122.0) | 104.0 (84.0–118.0) | 95.0 (80.0–110.0) | 104.5 (90.5–119.0) | >0.05 |
| TG (mg/dL) | 97.0 (68.0–154.0) | 81.5 (60.0–119.0) | 78.0 (65.0–96.0) | 82.0 (61.5–111.5) | 0.001 |
| Glucose (mg/dl) | 89.9 (85.0; 93.0) | 91.0 (84.5; 94.5) | 87.0 (84.0; 90.0) | 88.0 (84.5; 91.5) | >0.05 |
| Insulin (mU/ml) | 8.0 (5.5; 12.8) | 8.8 (5.2; 12.5) | 7.0 (5.6; 9.3) | 6.3 (4.9; 8.6) | 0.002 |
| Glucose after OGTT | 107.0 (89.0; 128.0) | 98.0 (83.0; 116.0) | 93.5 (80.0; 112.0) | 94.0 (85.0; 110.0) | 0.007 |
| Insulin after OGTT | 45.2 (27.4; 83.7) | 34.4 (22.5; 64.4) | 29.3 (19.0; 49.9) | 28.8 (20.9; 42.9) | 0.000 |
| LH (lU/L) | 7.9 (5.5–11.0) | 6.0 (3.6–7.5) c | 5.6 (4.7–6.7) | 6.8 (4.7–8.6) | 0.045 |
| FSH (lU/L) | 5.8 (4.9–6.6) | 6.0 (4.9–7.2) | 6.4 (5.2–7.4) | 5.9 (5.0–7.3) | >0.05 |
| LH/FSH | 1.3 (1.0–1.9) | 0.9 (0.6–1.4) | 0.8 (0.7–1.1) | 1.1 (0.8–1.4) | >0.05 |
| DHEA-S (µg/mL) | 310.9 (234.9–402.0) | 297.3 (230.5–383.1) | 336.4 (206.1–429.5) | 259.2 (192.9–310.9) | 0.010 |
| SHBG (nmol/L) | 47.5 (29.0–67.7) | 59.3 (31.2–90.0) | 69.2 (47.1–87.7) | 56.5 (42.9–82.5) | 0.001 |
| TT (ng/mL) | 0.4 (0.3–0.6) | 0.3 (0.2–0.5) | 0.3 (0.2–0.4) | 0.3 (0.2–0.3) | 0.001 |
| FT (pg/mL) | 1.9 (1.2–2.7) f | 1.3 (1.0–2.0) | 1.4 (0.9–2.3) | 1.0 (0.7–1.5) | 0.001 |
| FAI | 0.9 (0.5–1.5) | 0.5 (0.3–0.9) | 0.4 (0.2–0.9) | 0.4 (0.2–0.8) | 0.011 |
| AD (ng/mL) | 3.6 (2.6–4.6) | 3.0 (2.3–4.0) | 2.8 (2.2–3.6) | 2.3 (1.8–2.8) | 0.001 |
| 17-β-E2 (pg/mL) | 33.5 (22.9–47.2) | 35.2 (26.6–49.2) | 32.1 (23.8–39.1) | 29.9 (18.2–37.9) | 0.157 |
| 17α-OHP (nmol/L) | 1.8 (1.4–2.2) | 1.5 (1.2–1.9) | 1.5 (1.3–1.9) | 1.4 (1.2–1.8) | 0.003 |
| Cortisol (µg/dL) | 13.6 (11.1–16.1) | 13.7 (11.3–16.4) | 13.3 (10.2–14.8) | 13.2 (10.7–15.1) | 0.359 |
Values are shown as median with IQR or mean ± SD. Legend: PCOS—polycystic ovary syndrome; BMI—body mass index; WHR—waist-to-hip ratio; CHO—cholesterol; HDL-C—high density lipoprotein; LDL-C—low density lipoprotein; TG—triglycerides; LH—luteinizing hormone; FSH—follicle-stimulating hormone; DHEA-S—dehydroepiandrosterone sulfate; SHBG—sex hormone-binding globulin; TT—total testosterone; FT—free testosterone; FAI—free androgen index; AD—androstenedione; 17-β-E2—17 β-estradiol;17-OH P—17-α-hydroxyprogesterone.