Table 3.
Impact of genital high-risk HPV and human herpesvirus detection on cervical squamous intraepithelial lesions (SIL) in HIV-infected women.
| Genital hrHPV |
Genital HHV |
SIL-Negative No. (%) |
SIL-Positive No. (%) |
Odds Ratio (95% CI) |
p-valueb |
|---|---|---|---|---|---|
| Any HHV | |||||
| − | − | 95 (86.4) | 15 (13.6) | Reference | |
| + | − | 41 (51.9) | 38 (48.1) | 5.87 (2.91-11.83) | <.0001 |
| − | + | 18 (75.0) | 6 (25.0) | 2.11 (0.72-6.17) | .14 |
| + | + | 9 (39.1) | 14 (60.9) | 9.85 (3.63-26.76) | <.0001 |
| + | − | 41 (51.9) | 38 (48.1) | Reference | |
| + | + | 9 (39.1) | 14 (60.9) | 1.68 (0.65-4.33)a | .20 |
| EBV | |||||
| − | − | 100 (84.7) | 18 (15.3) | Reference | |
| + | − | 46 (52.3) | 42 (47.7) | 5.07 (2.64-9.75) | <.0001 |
| − | + | 13 (81.3) | 3 (18.7) | 1.28 (0.33-4.96) | .48 |
| + | + | 4 (28.6) | 10 (71.4) | 13.89 (3.94-49.15) | <.0001 |
| + | − | 46 (52.3) | 42 (47.7) | Reference | |
| + | + | 4 (28.6) | 10 (71.4) | 2.74 (0.80-9.40)a | .09 |
a
Odds ratio of SIL in women with both hrHPV and HHV (top of table) or EBV (bottom of table) compared to women with hrHPV but no HHV or EBV, respectively.
b
Fisher’s Exact Test p-value is presented.
Abbreviations: hrHPV, high-risk human papillomavirus. HHV, human herpesvirus. SIL, squamous intraepithelial lesion. CI, confidence interval. EBV, Epstein-Barr virus.