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. 2021 Sep 7;9:e12125. doi: 10.7717/peerj.12125

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© 2021 Zheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) The PPI network of DEGs was constructed in Cytoscape, Nodes represent proteins and edges represent interactions between two proteins. (B) The most significant module was obtained by MCODE plug-in. Red nodes represent upregulated DEGs and blue nodes represent downregulated DEGs. The diameters of nodes were positively correlated with their connectivity degree. (C) Hub genes selected by calculating the MCC scores of cytoHubba plugin.