Table 1.
Types of Umbilical Cord Blood (UCB) expansion.
| Type of UCB Expansion | Study | CD-34-Fold Expansion (Median) | Days of Expansion | Days to Neutrophil Engraftment (Median) |
|---|---|---|---|---|
| Cytokine expansion | Shpall et al. [16] | 1 | 10 | 28 |
| Copper chelation | de Lima et al. [17] | 2.2 | 21 | 30 |
| Notch-mediated | Delaney et al. [18] | NA | 16 | 16 |
| Mesenchymal stem cells (MSCs)-mediated | de Lima et al. [19] | 30.1 | 15 | |
| Nicotinamide-mediated | Horwitz et al. [20] | NA | 21 | 11.5 |
| StemRegenin 1-mediated | Wagner et al. [21] | NA | 15 | |
| Lysine-specific histone demethylase 1A (LSD1)-mediated | Subramaniam et al. [22] | 10 |