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. 2021 Sep 5;10(1):1760–1776. doi: 10.1080/22221751.2021.1971568

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6: — The impact of NS1 C-terminus variations on survival time and bodyweight gain in mice inoculated with H5N8 viruses. The estimated survival times are shown for BALB/C mice inoculated intranasally with a low-dose (103 pfu) (A, B) or a high-dose (105 pfu) (C, D) of H5N8-A (A, C) or H5N8-B (B, D). The relative bodyweight gain in BALB/C mice inoculated intranasally with a low-dose (E, F) or a high-dose (G, H) of H5N8-A (E, G) or H5N8-B (F, H) were calculated. A mock group were inoculated with 50 µL of sterile medium. Results show the relative mean bodyweight relative to the bodyweight immediately before infection (d0). Mice that lost more than 25% of their d0-bodyweight value were humanely euthanized and scored as dead. For clarity, standard deviations are not shown.