Table 2.

FMT studies in HSCT recipients for restoring gut microbiota and eradication of antibiotic-resistant bacteria.

Study	Indication	Number of Patients	Administration Route	Study Type	Donor Relation	Total Number of FMTs	Adverse Events	Response/Endpoint
Bilinski et al.[74]	Multidrug-resistant bacteria decolonization	20 (n = 8 allo-HSCT recipient; n = 12 other hematologic conditions)	Nasoduodenal tube	Prospective	Unrelated	25	No serious AEs	15/20 decolonization of multidrug-resistant bacteria
DeFilipp et al.[72]	Gut microbiota reconstitution following allo-HSCT	13	Oral capsules	Prospective	Unrelated	13	1 abdominal pain	Improved microbiome diversity
Taur et al.[73]	Gut microbiota reconstitution following allo-HSCT	25 (n = 14 received auto FMT; n = 11 no intervention)	Enema	Randomized controlled trial	Autologous FMT	25	No serious AEs	Restored gut microbiota to pre allo-HSCT state
Battipaglia et al.[75]	Multidrug-resistant bacteria decolonization	10 (n = 6 after allo-HSCT; n = 4 before allo-HSCT)	Enema/nasogastric tube	Retrospective	Unrelated/relative	13 (n = 9 after allo-HSCT)	No serious AEs	7/10 decolonization of multidrug-resistant bacteria

Abbreviation: FMT: Fecal microbiota transplantation, HSCT: Hematopoietic stem cell transplantation, Allo: Allogenic, GVHD: Fraft-versus-host disease, AE: Adverse event.