Table 1.
Antimicrobial resistance pattern and antibiotic therapy management of the gram-negative bacteria isolated by blood cultures and identified by the Verigene test.
| Escherichia coli(n 41) | Klebsiella Pneumoniae (n 9) | Pseudomonas aeruginosa (n 7) | Enterobacter (n 4) | Acinetobacter (n 3) | Citrobacter (n 2) | |
|---|---|---|---|---|---|---|
| Resistance markers | ||||||
| CTX-M | 10 | 5 | ||||
| KPC | 7 | 1 | ||||
| VIM | 1 | |||||
| OXA | ||||||
| Empirical therapy | ||||||
| PTZ | 33 | 6 | 3 | 3 | 2 | 2 |
| MEM | 3 | |||||
| MEM + VAN | ||||||
| Combo anti-CR | 2 | |||||
| Other | 8 | 2 | 1 | 1 | ||
| Therapeutic decision based on Verigene | ||||||
| De-escalation | ||||||
| Stop VAN | 6 | 2 | 1 | |||
| From MEM to PTZ | ||||||
| From combo anti-CR to MEM/PTZ | 2 | |||||
| No change/antibiotic-sparing approaches | 15 | 2 | 3 | 1 | 1 | |
| Escalation | ||||||
| From PTZ to MEM | 25 | 2 | 1 | 1 | 2 | 1 |
| From PTZ/MEM to combo anti-CR | 7 |
Abbreviations: CTX-M: Extended spectrum beta-lactamase, KPC: Klebsiella pneumoniae carbapenemase, VIM: Verona integrin-encoded carbapenem-resistant metallo-beta-lactamase, OXA: Oxacillin-resistant beta-lactamase, PTZ: Piperacillin/tazobactam, MEM: Meropenem, VAN: Vancomycin, CR: Carbapenem-resistant.