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. 2021 Sep 6;10(17):4021. doi: 10.3390/jcm10174021

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Multivariable stratified hazard analysis of the association between obesity and open-angle glaucoma. All adjusted hazard ratios in the multivariable stratified analysis were adjusted by the main model. The results in both the LHID2000 and LHID2005 displayed that obesity was a remarkable hazard of OAG in young (aged ≤40 years) obese adults compared with young non-obese adults. In gender stratification, the risk of OAG was more significant in obese men than non-obese men. As for the stratified analysis of covariates, in the LHID2005, the obese group without each covariate had an increased risk of OAG compared with the non-obese group without each covariate; however, the obese group with each covariate had a nonsignificant risk of OAG compared with the non-obese group with each covariate. There was a similar tendency in most of the stratified analyses of covariates in the LHID2000, but the analyses of hypertension and hyperlipidemia were inconsistent between the LHID2000 and LHID2005. There was no adjusted hazard ratio in a few subgroups (obesity with OSA in the LHID2005, and obesity with hypotension in both the LHID2000 and LHID2005). LHID = longitudinal health insurance database; OAG = open-angle glaucoma; OSA = obstructive sleep apnea; OPH = ophthalmology.