Table 2.

Multivariable cox proportional hazard regression of the association between open-angle glaucoma and potential risk factors.

	LHID2000				LHID2005
Variables	Crude HR (95% CI)	p-Value	aHR (95% CI)	p-Value	Crude HR (95% CI)	p-Value	aHR (95% CI)	p-Value
Exposure
Non-obesity	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Obesity	1.79 (1.41–2.27)	<0.001	1.43 (1.11–1.84)	0.006	1.85 (1.49–2.29)	122	1.54 (1.23–1.94)	<0.001
Gender
Female	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Male	1.23 (0.98–1.54)	0.076	1.21 (0.95–1.52)	0.120	1.16 (0.95–1.43)	0.153	1.19 (0.96–1.47)	0.109
Age
Age ≤ 40	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Age > 40	3.83 (2.94–5.00)	<0.001	3.09 (2.26–4.25)	<0.001	4.75 (3.66–6.15)	<0.001	3.52 (2.64–4.70)	<0.001
Comorbidity
Diabetes
No	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Yes	2.91 (2.31–3.66)	<0.001	1.55 (1.18–2.04)	0.002	3.04 (2.47–3.73)	<0.001	1.61 (1.26–2.06)	<0.001
Hypertension
No	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Yes	2.68 (2.16–3.34)	<0.001	1.22 (0.92–1.61)	0.170	3.00 (2.46–3.67)	<0.001	1.38 (1.07–1.77)	0.012
Hyperlipidemia
No	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Yes	2.51 (2.01–3.12)	<0.001	1.14 (0.87–1.50)	0.347	2.27 (1.86–2.78)	<0.001	0.90 (0.71–1.15)	0.412
IHD
No	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Yes	2.66 (2.08–3.42)	<0.001	1.27 (0.95–1.68)	0.106	2.60 (2.07–3.25)	<0.001	(1.170.91–1.50)	0.231
CKD
No	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Yes	2.17 (1.29–3.64)	0.003	1.02 (0.60–1.74)	0.934	2.05 (1.28–3.30)	0.003	0.93 (0.57–1.51)	0.764

CKD = chronic kidney disease; IHD = ischemic heart disease; IRR = incidence rate ratio; LHID = Longitudinal Health Insurance Database OAG = open-angle glaucoma.