TABLE 2.
Descriptive statistics of the MICs obtained by testing 105 strains their susceptibilities to both fluconazole and flucytosine
| Fluconazolea
|
Flucytosineb
|
|||||||
|---|---|---|---|---|---|---|---|---|
| C. albicans genotype A | C. albicans genotype B | C. albicans genotype C | C. dubliniensis | C. albicans genotype A | C. albicans genotype B | C. albicans genotype C | C. dubliniensis | |
| Mean MIC (μg/ml) | 22.8 | 33.4 | 32.3 | 4.7 | 6.9 | 0.26 | 2.3 | 8.7 |
| SD MIC (μg/ml) | 29.8 | 29.1 | 30.5 | 9.3 | 3.5 | 0.07 | 2.1 | 5.8 |
| Geometric mean MIC (μg/ml) | 4.2 | 10.3 | 8.9 | 1.1 | 0.54 | 0.18 | 0.22 | 0.32 |
| No. of isolates | 30 | 30 | 30 | 15 | 30 | 30 | 30 | 15 |
| Confidence level (95.0%) | 11.1 | 10.8 | 11.4 | 5.2 | 7.2 | 0.14 | 4.3 | 12.4 |
ANOVA for the fluconazole susceptibility results of the four groups gave a P value of 0.003. Analysis of each pair of groups by a two-sample t test assuming unequal variance showed that the results for C. dubliniensis were significantly different from those for each of C. albicans genotypes A, B, and C (P = 0.018, 0.002, and 0.004, respectively). No other statistically significant differences were observed.
ANOVA for the flucytosine susceptibility results for the four groups gave a P value of 0.021. Analysis of each pair of groups by a two-sample t test assuming unequal variance showed that the results for the C. albicans genotype A strains were significantly different from those for each of C. albicans genotypes B and C (P = 0.004 and 0.003, respectively). No other statistically significant differences were observed.