TABLE 5.

Gene ontology categories that are significantly enriched in terms of biological processes and molecular functions differentially regulated between LEO-treated samples and control samples

GO code	Term	No. of genes differentially expresseda	FDR P value	Regulation
Biological process
0040011	Locomotion	5/32	0.054026	Down
0071973, 0097588, 0001539, 0048870, 0006928	Cilium or flagellum-dependent cell motility	3/23	0.012148	Down
0065007	Biological regulation	19/83	0.062751	Down
0044271	Cellular nitrogen compound biosynthetic process	65/183	1.62E−10	Up
0006430	Transfer RNA aminoacylation	2/22	0.006264	Up
0006807	Nitrogen compound metabolic process	87/433	2.16E−08	Up
Molecular function
0046873	Metal ion transmembrane transporter activity	2/16	0.061105	Down
0015103	Organic anion transmembrane transporter activity	4/10	0.085316	Down
0019843	rRNA binding	27/39	1.51E−15	Up
0003735	Structural constituent of ribosome	36/52	1.00E−15	Up
0005198	Structural molecule activity	37/59	1.14E−14	Up
0097159, 1901363	Organic cyclic compound binding	93/436	0.006437	Up
0003676	Nucleic acid binding	54/175	4.16E−05	Up
0000049	tRNA binding	6/18	0.009744	Up
0005488	Binding	113/588	0.048065	Up
0140101	Catalytic activity, acting on a tRNA	2/43	0.048065	Up
0004812, 0016875	Aminoacyl-tRNA ligase activity	2/22	0.005088	Up
0140098	Catalytic activity, acting on RNA	9/64	0.069198	Up

^aAbsolute log₂ fold change of ≥1; false discovery rate [FDR] P value of ≤0.05 relative to total number of genes in enriched category.