FIG 1.

Inactivation of SARS-CoV-2 by heat treatment under different procedures. (A) A solution of SARS-CoV-2 was exposed to 70°C heat. Samples were placed in uncovered or covered 24-well plates, or in closed 2-ml vials before heat treatment using a dry oven or a heat block containing water. (B) Samples were then collected at the indicated time points during heat treatment. Viable virus titer estimated by endpoint titration is shown in TCID₅₀/ml medium on a logarithmic scale. Points show estimated titers for each collected sample; vertical bar shows a 95% credible interval. Time-points with no positive wells for any replicate are plotted as triangles at the approximate single-replicate detection limit of the assay (LOD, denoted by a black dotted line at 10^0.5 TCID₅₀/ml medium) to indicate that a range of sub-LOD values are plausible. Lines show predicted decay of virus titer over time (10 random draws per data point from the joint posterior distribution of the slope and intercept). Panel A created with BioRender.com.