Fiber intake quintiles
	Q1	Q2	Q3	Q4	Q5	P for interaction
Total fiber intake	1.01(0.89,1.16)	1.09(0.98,1.22)	1.06(0.96,1.17)	0.90(0.82,1.00)	0.93(0.82,1.05)	0.04
Soluble fiber intake	0.98(0.86,1.12)	1.04(0.92,1.07)	0.98(0.88,1.08)	0.92(0.83,1.01)	0.98(0.88,1.09)	0.19
Insoluble fiber intake	1.03(0.91,1.17)	0.96(0.86,1.08)	1.04(0.94,1.15)	0.97(0.88,1.07)	0.89(0.80,0.99)	0.09

¹Comparing high vs low total lignan intake.

²Data were combined from three cohorts.

Models were age- (months) and calendar-time stratified and adjusted for ethnicity (white, African American, Asian, others), smoking status (never smoked, past smoker, currently smoke 1–14 cigarettes per day, 15–24 cigarettes per day, or ≥25 cigarettes per day), time-varying BMI (<21.0, 21.0–22.9, 23.0–24.9, 25.0–26.9, 27.0–29.9, 30.0–32.9, 33.0–34.9, or ≥35.0 kg/m²), alcohol intake (0, 0.1–4.9, 5.0–9.9, 10.0–14.9, 15.0–29.9, and ≥30.0 g/d), multivitamin use (yes, no), physical activity (quintiles), healthy plant-based diet index (quintiles), and family history of myocardial infarction. For women, postmenopausal hormone use (premenopausal, never, former, current, or missing), and oral contraceptive use were further adjusted.