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. 2021 Feb 26;38(6):746–755. doi: 10.1089/neu.2020.7297

FIG. 1.

FIG. 1.

Contusion spinal cord injury (SCI) results in edema and elevated intraspinal pressure (ISP). (A) Intact rodent thoracic spinal cords have average water content of 66.7 ± 0.01%. (Red dotted line). At 3 days after SCI, a significant increase in water content (78.21 ± 1.85%; p < 0.05, n = 3) was detected. Water content was measured within 40 mm of spinal cord centered over the injury site. Spinal cords segments (5 mm) were collected and the wet and dry weight of the cord segments were collected to determine water content of the spinal cord. (B) Three days after injury, the ISP was significantly increased (7.9 ± 0.6 mmHg) compared with control animals (1.84 ± 0.5 mmHg; p < 0.001). Durotomy alone (4.17 ± 0.3 mmHg; p < 0.001) and durotomy plus myelotomy (3.14 ± 0.4 mmHg; p < 0.001) resulted in significantly decreased ISP compared with SCI alone group. R = rostral, C = caudal directions. ***p < 0.001. Color image is available online.