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p38 inhibitor (SB203580) downregulated CCL2 and CCR2 mRNA expression. CCL2 and CCR2 mRNA expression decreased significantly at 3 days after continuous injection of high doses of p38 inhibitor. Values are expressed as mean ± SEM (n = 6/group). **P < 0. 01, *P < 0.05, vs. TBI + vehicle group; ###P < 0.001, vs. sham group. TBI, traumatic brain injury.
