Figure 6.

Immunohistochemistry for expression of tight junction proteins in colonic biopsies of healthy dogs and dogs with CIE before and after probiotic VSL #3 therapy. Healthy dogs generally express increased TJPs as compared to dogs with CIE at diagnosis (pre-VSL #3). A reciprocal increase in TJP expression is observed in dogs with CIE following probiotic treatment (post-VSL #3). (A) Claudin expression; (B) E-cadherin expression; (C) Occludin expression. All images at 20X magnification. From: White et al. (141), with permission.