Figure 7.

Immunohistochemical detection of proliferating epithelial cells in mice treated with hypoxoside. Mice were either sham treated orally with sterile drinking water (Control) or hypoxoside (Colonized and treated). The mice treated daily with either saline or hypoxoside (15 mg) beginning 8 days prior to colonization with Brachyspira hyodysenteriae (B. hyo). Mice were necropsied 3 days after colonization. One h prior to necropsy, mice received an IP injection of BrDU. Proliferating epithelial cells were identified by labeling their DNA with anti-BrDU using immunohistochemistry. From: (149), with permission.