Figure 4.

Measurement of plasma coagulation time and fibrinogen concentration: Fresh human plasma was co-incubated with 100 μg/mL of graphene derivatives for 30 min at 37 °C. Plasma coagulation was induced by the addition of sodium citrate and activated partial thromboplastin time (aPTT) (A); prothrombin time (PT) (B) and fibrinogen concentration (C) were recorded, respectively. One-way analysis of variances with Dunnett’s multiple comparison test was applied. Significant results are indicated as * p < 0.05; ** p < 0.01 and *** p < 0.001.