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. Author manuscript; available in PMC: 2022 Mar 6.
Published in final edited form as: Nat Genet. 2021 Sep 6;53(9):1348–1359. doi: 10.1038/s41588-021-00920-0

Fig. 4. Landscape of mutational processes in Sherlock-Lung.

Fig. 4

Mutational signature profile of single base substitutions (SBS) across 232 Sherlock-Lung samples. Panels from top to bottom: 1) Unsupervised clustering based on the proportion of SBS signatures; 2) Tumor histological type; 3) SCNA cluster; 4) Pie chart showing the percentage of mutations contributed to each SBS signature and the barplot presenting the total number of SNVs assigned to each SBS signature; 5) Cosine similarity between original mutational profile and signature decomposition result; 6) Proportions of SBS mutational signatures in each sample. 7) Proportions of SBS mutational signatures in each SCNA subtype.