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. Author manuscript; available in PMC: 2022 Mar 6.
Published in final edited form as: Nat Genet. 2021 Sep 6;53(9):1348–1359. doi: 10.1038/s41588-021-00920-0

Extended Data Fig. 1. Genomic alterations of RTK-RAS pathway in Sherlock-Lung.

Extended Data Fig. 1

a, Oncoplot showing mutual exclusivity of genes within the RTK-RAS pathway, which were used to define the RTK-RAS status. The bottom bar shows tumor histological types. b, Comparison of genomic features between RTK-RAS negative and positive tumors. Left four panels: tumor mutational burden, percentage of genome with SCNAs, SV burden and T/N TL ratio. P-values are calculated using the two-sided Mann-Whitney U test; Middle three panels: enrichments for Kataegis events, WGD events, and BRCA2 LOH. P-values and OR are calculated using Fisher’s exact test (two-sided); Right panel: Contributions of each SBS signature.