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. 2021 Aug 30;17(8):e1009786. doi: 10.1371/journal.pgen.1009786

Fig 5. Prl8a2 overexpression rescued pregnancy failure in LPS-treated Notch2 d/d mice.

Fig 5

(A) Lentivirus-mediated Prl8a2 overexpression prompted P4 secretion by cultured CL cells. (B) Virus injection and LPS treatment was carried out as illustrated. (C) Overexpression of Prl8a2 in Notch2 d/d mice rescued LPS-induced pregnancy failure. (D) H&E staining revealed normal embryo development in most implantation sites of LPS-treated Notch2 d/d mice after Prl8a2 overexpression. Arrowhead indicates abortion-induced decidual shedding. Scale bar: 300μm. (E) The serum P4 level was compared in LPS-treated Notch2 d/d mice with or without Prl8a2 overexpression. (F) The relative mRNA level of genes related to P4 synthesis or degradation in ovaries of LPS-treated Notch2 d/d mice with or without Prl8a2 overexpression. Data in (A), (E) and (F) are presented as mean±SEM. *p<0.5, **p<0.01, ***p<0.001.