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. 2021 Sep 10;16(9):e0257084. doi: 10.1371/journal.pone.0257084

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© 2021 Kafita et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Showing the top-ranked enriched (a) KEGG pathway and (b) GO Molecular functions in the subtype-1 tumours compared to the subtype-2 tumours. (c) A network of the genes that encompass the KEGG pathways “mTOR signalling pathway” that we found significantly enriched in subtype-1 tumours compared to subtype-2 tumours. The nodes are coloured using the degree of statistical significance for each protein (negative logarithm of the p-values) between subtype-1 and subtype-2 tumours. (d) A network of the genes that encompass the GO-term molecular function “Purine Ribonucleoside Triphosphate Binding” that we found significantly enriched in the subtype-1 compared to the subtype-2 tumours. The nodes are coloured based on the degree of statistical significance for each protein (negative logarithm of the p-values) between subtype-1 and subtype-2 tumours with redder colours indicating a higher level of statistical significance.