Fig 4.

(a) The integrated plot of gene mutations, copy number alterations and the clinical features of the pancreatic tumours and the afflicted patients. From top to bottom panels indicate the proteomic subtypes of pancreatic cancer; the tumour location in the pancreas; the histological subtypes of the tumours; age at diagnosis; the patient’s gender; the tumour’s histological grade; non-silent mutations and copy number alteration frequency in each tumour across the altered genes. The key to the number coding of tumour location is 1; head, 2; body, 3; other, 4; tail. The number coding of histological diagnosis is 1; Pancreas-Adenocarcinoma-Other Subtype, 2; Pancreas-Colloid (mucinous non-cystic) Carcinoma, 3; Pancreatic Ductal Adenocarcinoma, 4; Discrepancy. (b) Mutual exclusivity of SMAD4 and CDKN2A mutations. (c) Gene alterations in the cell cycle pathways genes. (d) Gene alterations in the TGF-beta pathway genes.