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. 2021 Aug 30;17(8):e1009425. doi: 10.1371/journal.ppat.1009425

Fig 5. Mutation of tatA or exposure to the Tat inhibitor Bayer 11–7082 inhibits pqsA expression and AQ production.

Fig 5

(A) Mutation of tatA or (B) treatment with Bayer 11–7082 supplied at either 20 μM or 40 μM reduces the maximal expression of a P. aeruginosa PAO1 chromosomal pqsA’-lux promoter fusion without affecting growth. (C) LC-MS/MS analysis of PQS production by P. aeruginosa PAO1 wild type compared with the tatA mutant and complemented tatA mutant. Experiments were repeated in triplicate at least twice. ***p < 0.001; n.s. not significant.