Table 4. Comparison of serum NFL concentrations according to COVID-19 treatment.
Regression coefficients, 95% CIs, and P values result from linear regression models, where NFL was the dependent variable. Regression coefficients are interpreted as the difference in mean NFL concentration (on the natural logarithmic scale) between patients who had the given treatment and patients who did not have the given treatment. P values <0.0063 were considered as statistically significant after applying a Bonferroni correction for multiple testing.
|
COVID-19
treatment |
N |
Median (minimum,
maximum) NFL concentration |
Adjusting for time from admission to
blood draw |
Adjusting for age, sex, BMI, and time from
admission to blood draw |
||
|
Regression
coefficient (95% CI) |
P value |
Regression
coefficient (95% CI) |
P value | |||
| Monoclonal antibody treatment | ||||||
| First NFL value per patient | ||||||
| No treatment | 125 | 22.5 (2.9, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 17 | 20.0 (3.5, 647.3) | −0.34 (−0.91, 0.23) | 0.29 | −0.47 (−1.00, 0.05) | 0.074 |
| Final NFL value per patient | ||||||
| No treatment | 107 | 31.1 (2.2, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 35 | 33.4 (3.1, 1465.8) | −0.38 (−0.85, 0.09) | 0.12 | −0.39 (−0.84, 0.07) | 0.094 |
| Remdesivir treatment | ||||||
| First NFL value per patient | ||||||
| No treatment | 92 | 21.2 (2.9, 872.3) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 50 | 23.7 (3.4, 1538.4) | −0.25 (−0.68, 0.18) | 0.25 | −0.24 (−0.64, 0.15) | 0.23 |
| Final NFL value per patient | ||||||
| No treatment | 42 | 32.3 (3.4, 1359.7) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 100 | 32.1 (2.2, 1538.4) | −0.47 (−0.89, −0.05) | 0.029 | −0.56 (−0.97, −0.15) | 0.008 |
| Dexamethasone treatment | ||||||
| First NFL value per patient | ||||||
| No treatment | 103 | 21.4 (2.9, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 39 | 22.5 (3.4, 872.3) | 0.27 (−0.16, 0.69) | 0.22 | 0.26 (−0.13, 0.64) | 0.19 |
| Final NFL value per patient | ||||||
| No treatment | 66 | 29.3 (2.2, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 76 | 37.8 (3.1, 1465.8) | −0.11 (−0.51, 0.29) | 0.59 | −0.08 (−0.46, 0.31) | 0.69 |
| Convalescent plasma treatment | ||||||
| First NFL value per patient | ||||||
| No treatment | 119 | 20.3 (2.9, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 23 | 33.4 (9.4, 647.3) | −0.24 (−0.82, 0.35) | 0.43 | −0.25 (−0.78, 0.28) | 0.35 |
| Final NFL value per patient | ||||||
| No treatment | 107 | 27.1 (2.2, 1538.4) | 1.00 (reference) | N/A | 1.00 (reference) | N/A |
| Treatment | 35 | 40.0 (3.1, 1186.2) | −0.01 (−0.46, 0.45) | 0.98 | −0.02 (−0.41, 0.45) | 0.93 |