Fig. 5.

Schematic figure. Efficient biomicro/nano topographic material development procedure. (A–B) Develop cell culture devices based on this guideline to remove or control confounding factors before initiating biotopographic cell response research projects, then provide a “cell culture devices qualification report” to report the information of structural parameters and controlling for all the related confounding factors. (C–D) Initiate cell response research then provide a “minimum information report” that recording all the conditions when carrying out cell culture and analysis. (E–F) Obtain highly reusable “one structural parameter – one set of cell response” data and establish a high-quality database. (G) Virtual topographic structures prediction, screening and design based on the high-quality database.