Table 3.

Correlation analysis between TBC1D3 and relate genes and markers of immune cells in KIRC by TIMER.

	Gene markers	KIRC
		None		Purity
		Correlation	p	Correlation	p
CD8+ T cell	CD8A	0.077	ns	0.062	ns
	CD8B	0.061	ns	0.053	ns
T cell (general)	CD3D	0.072	ns	0.054	ns
	CD3E	0.101	∗	0.085	ns
	CD2	0.111	∗	0.093	∗
B cell	CD19	0.133	∗	0.117	∗
	CD79A	−0.022	ns	−0.014	ns
Monocyte	CD86	0.051	ns	0.072	ns
	CD115 (CSF1R)	0.099	ns	0.112	∗
TAM	CCL2	−0.008	ns	−0.028	ns
	CD68	0.006	ns	0.031	ns
	IL10	0.068	ns	0.18	ns
M1 macrophage	INOS (NOS2)	−0.003	ns	−0.002	ns
	IRF5	0.365	∗∗∗	0.358	∗∗∗
	COX2 (PTGS2)	−0.001	ns	−0.044	ns
M2 macrophage	CD163	0.034	ns	0.067	ns
	VSIG4	0.054	ns	0.079	ns
	MS4A4A	0.031	ns	0.049	ns
Neutrophils	CD66b (CEACAM8)	0.169	∗∗∗	0.166	∗∗∗
	CD11B (ITGAM)	0.151	∗∗∗	0.168	∗∗∗
	CCR7	0.088	ns	0.09	ns
Natural killer cell	KIR2DL1	0.022	ns	0.018	ns
	KIR2DL3	0.049	ns	0.07	ns
	KIR2DL4	0.061	ns	0.067	ns
	KIR3DL1	−0.02	ns	−0.017	ns
	KIR3DL2	0.004	ns	−0.009	ns
	KIR3DL3	−0.002	ns	−0.016	ns
	KIR2DS4	−0.027	ns	−0.029	ns
Dendritic cell	HLA-DPB1	0.011	ns	0.025	ns
	HLA-DQB1	0.056	ns	0.065	ns
	HLA-DRA	0	ns	0.02	ns
	HLA-DPA1	0.023	ns	0.032	ns
	BDCA-1 (CD1C)	0.043	ns	0.057	ns
	BDCA-4 (NRP1)	0.041	ns	0.065	ns
	CD11c (ITGAX)	0.424	∗∗∗	0.436	ns
Th1	T-bet (TBX21)	0.241	∗∗∗	0.24	∗∗∗
	STAT4	0.366	∗∗∗	0.363	∗∗∗
	STAT1	0.079	ns	0.082	ns
	IFN-γ (IFNG)	0.176	∗∗∗	0.172	∗∗∗
	TNF-α (TNF)	0.249	∗∗∗	0.245	∗∗∗
Th2	GATA3	0.062	ns	0.065	ns
	STAT6	0.357	∗∗∗	0.383	∗∗∗
	STAT5A	0.163	∗∗∗	0.177	∗∗∗
	IL13	0.36	∗∗∗	0.327	∗∗∗
T fh	BCL6	0.347	∗∗∗	0.332	∗∗∗
	IL21	0.069	ns	0.071	ns
Th17	STAT3	0.093	ns	0.012	∗∗
	IL17A	0.002	ns	−0.023	ns
Treg	FOXP3	0.2	∗∗∗	0.187	∗∗∗
	CCR8	0.187	∗∗∗	0.199	∗∗∗
	STAT5B	0.163	∗∗∗	0.177	∗∗∗
	TGF-β (TGFB1)	0.017	ns	0.011	ns
T cell exhaustion	PD-1 (PDCD1)	0.171	∗∗	0.15	∗∗
	CTLA4	0.33	∗∗∗	0.314	∗∗∗
	TIM-3 (HAVCR2)	−0.024	ns	−0.015	ns
	GZMB	0.046	ns	0.05	ns
	LAG3	0.167	∗∗∗	0.141	∗∗∗
	PDL1 (CD274)	0.106	∗∗	0.099	∗

TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. ∗ p < 0.01; ∗∗ p < 0.001; ∗∗∗ p < 0.0001.