Fig. 4.

The genomic and epigenetic landscape of the PCa subtypes in TCGA-PRAD. (A) Comparison of mean miRNA expression level among four PCa subtypes and normal samples. (B) A Venn diagram shows the number of unique and overlapping differentially expressed miRNAs (DEmiRs) among subtypes. (C) GSEA of subtype-specific DEmiRs identifies a subset of miRNAs that significantly contribute to the mRNA expression profiles of corresponding subtypes. (D) The levels of promoter methylation, somatic mutation, tumor neoantigen and aneuploidy were compared across subtypes. (E) The burden of copy number gain and loss at focal and arm levels in the four PCa subtypes. Oncoprints of top 20 somatic mutations (F) and somatic recurrent copy number alterations (G) among subtypes. The proportion of alteration of listed genes was shown on the right side. “ns” denotes no statistical significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.