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. 2021 Sep 10;10(9):60. doi: 10.1038/s41389-021-00350-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A GSEA showed that TRIM3 expression correlated positively with ESR1-activated gene signatures and negatively with ESR1-suppressed gene signatures in ER⁺ breast cancer profiles (TCGA, n = 400). B Estrogen response element (ERE) luciferase reporter activity was analyzed in the indicated cells treated with E2 (10 nM) and/or TAM (1 μM). Data are presented as the mean ± SD. *P < 0.05. C Heatmap of ER-regulated gene expression in the indicated cells treated with E2 and TAM.