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. 2020 Oct 5;6:76. doi: 10.1038/s41378-020-00185-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Diagram demonstrating the current challenges in (a) conventional organoid and spheroid production techniques including lack of proper nutrient delivery and exchange, as well as lack of size reproducibility. b Microfabricated and microfluidic-based approaches allow for array production with improved media exchange, as well as improved size control due to a defined culture area