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. 2021 Sep 10;12:5373. doi: 10.1038/s41467-021-25710-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a METTL14 expression in MSC was increased and ELMO1 expression was inhibited in the OE-M14 group (n = 9) compared to the control group (n = 9; P = 1.3363E−11, 8.9609E−13) and OE-NC group (n = 9; P = 1.2451E−11, 7.4978E−13). b The m⁶A modification level of ELMO1 mRNA in OE-M14 group (n = 9) was higher than that of control group (n = 9; P = 0.001) and OE-NC group (n = 9; P = 0.000092). c, d The degeneration rate of ELMO1 mRNA was elevated by OE-M14 group (n = 9) than OE-NC group (n = 9; P = 0.029). e The active Rac1 level in MSC (n = 9) was significantly lower in OE-M14 group (n = 9; P = 1.3512E−10) than the OE-NC group (n = 9; P = 2.0426E−11). f The number of stained migratory MSC in OE-M14 group (n = 9) was lower than that of control group (n = 9; P = 0.001) and OE-NC group (n = 9; P = 0.005). g The migratory area of the OE-M14 group (n = 9) was smaller compared to that of control group (n = 9; P = 0.005) and OE-NC group (n = 9; P = 0.011). h The bioluminescence area of nude mice in the OE-M14 group (n = 9) was lower than that of mice in the control group (n = 9; P = 0.002) and the OE-NC group (n = 9; P = 0.013). Data were analyzed using one-way ANOVA followed by Bonferroni’s post hoc comparisons. Values are presented as the mean ± SD. * Indicates P < 0.05, ** indicates P < 0.01, and *** indicates P < 0.001. W/O indicates MSC without lentivirus transfection. OE-NC indicates MSC transfected with control lentiviruses. OE-M14 indicates MSC transfected with lentiviruses overexpressing METTL14.