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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neurogastroenterol Motil. 2021 Mar 11;33(10):e14116. doi: 10.1111/nmo.14116

Table 3.

Clinical and manometric characteristics by FLIP Panometry contractile response pattern.

Contractile response pattern Normal contractile response Borderline diminished contractile response Impaired disordered contractile response Spastic-Reactive contractile responsea Absent contractile response
n 70 56 20 13 5
Age (yrs), mean (SD) * 42 (15) 52 (15) 52 (15) 67 (12) 45 (20)
Gender (female), n (%) * 50 (71) 49 (88) 12 (60) 8 (62) 1 (20)
Body mass index (kg/m2), median (IQR) 24 (21–28) 25 (20–31) 26 (23–30) 26 (23–29) 25 (23–30)
Indication, n (%)
 Dysphagiaa 57 (81) 41 (73) 17 (85) 10 (77) 4 (80)
 Reflux symptoms 12 (17) 8 (14) 2 (10) 1 (8) 1 (20)
 Chest pain 1 (1) 6 (11) 1 (5) 1 (8) 0
 Other 0 1 (2) 0 1 (8) 0
GerdQ,
 Completed, n (%) 59 (84) 43 (77) 17 (85) 8 (62) 4 (80)
 median [IQR] 9 (7–10) 9 (6–11) 8 (7–12) 10 (9–11) 10 (8–12)
BEDQ,
 n (%) completed 55 (79) 44 (79) 15 (75) 8 (62) 4 (80)
 median [IQR] 8 (3–18) 13 (4–18) 8 (0–17) 6 (2–23) 14 (6–29)
Sedation strategy, n(%)
Conscious sedation 67 (95) 50 (89) 18 (90) 12 (92) 4 (80)
Monitored anesthesia care 3 (4) 2 (10) 2 (10) 1 (8) 1 (20)
Endoscopy findings, n (%)
 LA grade A/B 3 (4) / 5 (7) 3 (5) / 2 (4) 2 (10) / 1 (5) 1 (8) / 0 1 (20) / 0
 Widely patent ring 3 (4) 4 (7) 0 0 0
 Epiphrenic diverticulum 1 (1) 0 0 2 (15) 0
HRM findings
IRP, mmHg, mean (SD) 9 (3) 9 (4) 9 (4) 11 (3) 11 (2)
Basal EGJ pressure, mmHg, median (IQR) 14 (8–22) 14 (9–21) 13 (8–30) 12 (9–17) 8 (5–25)
EGJ morphology, n(%)b
 Type 1 55 (80) 37 (66) 18 (90) 9 (62) 2 (40)
 Type 2–3 14 (20) 19 (34) 2 (10) 4 (31) 3 (60)
Median DCI, mmHg•cm•s, median (IQR) 1715 (1219–2584) 1968 (997–3293) 1563 (909–2046) 2675 (1132–3327) 598 (534–2907)
Abnormal TBE, n/nbb(%) 8/25 (32) 7/26 (27) 5/8 (63) 3/7 (43) 1/2 (50)
Barium retention, n/nb(%) 5/25 (20) 5/26 (19) 3/8 (38) 2/7 (29) 1/2 (50)
Tablet retention, n/nb(%) 4/25 (16) 2/26 (8) 2/8 (25) 1/7 (14) 0/2 (0)
FLIP
EGJ-DI, mm 2 /mmHg, median (IQR) * 5.4 (4.5–6.9) 3.7 (2.4–6.6) 2.4 (1.8–3.7) na 3.0 (1.6–4.6)
Maximum EGJ diameter, mm, median (IQR) * 20 (19–21) 19 (17–21) 16 (14–18) na 15 (11–15)
*

(bold) P<0.05 for comparison across five groups.

a

Note redundancy in reporting with Table 1, but included here for comparison.

b

P = 0.065 for comparison across five groups.

b

n(%) of patients that completed timed barium esophagram (TBE) with barium tablet. BEDQ - Brief Esophageal Dysphagia Questionnaire. DCI – distal contractile integral. DI - distensibility index. EGJ – esophagogastric junction. HRM - high resolution manometry. IRP – integrated relaxation pressure. na – not applied. TBE - Timed barium esophagram.