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. 2021 Mar 3;7:19. doi: 10.1038/s41378-021-00245-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Microfluidic-based vascular system to investigate the relationships of platelet aggregation time and blood volume with shear rates. d, e HUVEC-modified microfluidic chip, scale bars: 15 mm (d) and 200 μm (e). f Formation of fibrin (green) along with platelet aggregates (red), scale bar: 20 μm. g Microfluidic chips perfused with blood, scale bars: 370 μm. h Formation of thrombosis in stenotic geometry, scale bars: 200 μm. i Vasculature-on-a-chip to mimic the blood flow in vessels (i1); Mitochondrial morphology of endothelial cells without (i2) or with (i3) glucose under different shear stresses. a–c Reproduced with permission⁴⁰. Copyright 2012, The Royal Society of Chemistry. d–f Reproduced with permission⁴⁶. Copyright 2016, Springer Nature. g, Reproduced with permission⁴⁸. Copyright 2017, The Royal Society of Chemistry. i Reproduced with permission⁴⁴. Copyright 2019, The Royal Society of Chemistry.