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. 2020 Feb 10;6:4. doi: 10.1038/s41378-019-0118-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a The real-time monitoring phase shift signals of the specific binding of the aptamer and the endotoxin at different concentrations. b Histogram of the specific binding of the aptamer to the endotoxin at different concentrations. c Standard curve for the quantitative detection of an endotoxin with an SH-SAW biosensor based on single-layered graphene. The phase shift on the y-axis had a linear relationship with the increasing concentrations of endotoxin on the x-axis. Each data point represents an average of at least three measurements ± the standard deviation. d The real-time phase signals of the endotoxin obtained from E. coli, the endotoxin obtained from P. aeruginosa, and the aflatoxin binding with the aptamer, which were all analyzed at concentrations of 50 ng/mL.