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. 2021 Sep 10;11:18084. doi: 10.1038/s41598-021-97522-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL6 expression is increased by laser and expressed at the laser injury site. 20X magnification of paraffin-embedded sections stained for hematoxylin and IL6 (pink, RNAscope) from Il6^−/− (A) and wildtype (B) mice. Arrows indicate laser lesion. 40X magnification of sections stained for hematoxylin and IL6 (pink, RNAscope) from Il6^−/− (C) and wildtype (D, H) mice. Green arrows indicate IL6 + cells. 40 $\times$ magnification with digital zoom of IL6 (E), IBA1 (F), and F4/80 (G) in serial sections from a single lesion. Light green, dark green, and yellow arrows indicate IL6 + cells co-staining for IBA1 and F4/80 in serial sections. ELISA measurements (I) of IL6 expression demonstrate a 1.15-fold (*** = p < 0.001, N = 4–5 per group) increase after laser injury.