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. 2021 Sep 10;11:18084. doi: 10.1038/s41598-021-97522-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL6R is expressed in ocular monocytes and macrophages. (A) CD64⁺Cx3cr1⁺ cells were gated forward. (B) Microglia were defined as CD45^dimCx3cr1⁺ while all other cells were determined to be macrophages (Boolean gate). (C) Non-Cx3cr1⁺CD64⁺ cells were gated forward from (A) and dendritic cells (DC) were defined as MHCII⁺CD11c⁺. (D) Non-MHCII⁺CD11c⁺ cells from (C) were gated forward and monocytes were defined as CD45^highCx3cr1⁺. E–H: Representative frequency histograms for IL6R expression from the fluorescence minus one (FMO) control, untreated (No Laser, Blue), and lasered (Laser, Red) mice in monocytes (E), macrophages (F), microglia (G), and dendritic cells (DC, H). I: At steady state, monocytes expressed the IL6R. The number of IL6R⁺ macrophages were increased by laser (** = p < 0.01, *** = p < 0.001, blue asterisks indicate differences from unlasered mice, red asterisks indicate differences from lasered mice, N = 3 per group).