Table 1.
Comparison of viability and spheroid formation for the three culture conditions tested in this paper
| PDX models | Histotype | Viability (%) at day 14 | Spheroids Size (fold increase) at day 14 | |||
|---|---|---|---|---|---|---|
| Matrigel | Standard | Microfluidic | Standard | Microfluidic | ||
| PH039 | Serous | 65 ± 16.5a | 66 ± 8.3a | 87 ± 8.0 | 1.3 ± 0.14a | 1.7 ± 0.24 |
| PH063 | Serous | 86 ± 4.8a | 61 ± 3.6a | 95 ± 2.4 | 1.1 ± 0.08a | 1.6 ± 0.18 |
| PH592 | MMMT | 83 ± 5.0a | 60 ± 11.9a | 88 ± 3.7 | 1.1 ± 0.11a | 1.8 ± 0.16 |
| PH704 | Serous | 82 ± 6.6 N.S. | 58 ± 5.1a | 86 ± 2.7 | 1.1 ± 0.12a | 1.3 ± 0.13 |
| PH757 | Serous | 84 ± 1.3a | 66 ± 15.2a | 99 ± 0.3 | 1.7 ± 0.42a | 2.5 ± 0.19 |
| PH938 | Serous | 85 ± 8.7a | 79 ± 12.9a | 96 ± 1.6 | 1.3 ± 0.11a | 1.6 ± 0.14 |
aSignificantly lower (p < 0.05) compared to the values from the microfluidic culture format (n = 6)
NS Not significant difference (p < 0.05) compared to the values from the microfluidic device (n = 6)