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GCH1 negatively regulates the expression of mmu-miR-1a-3p and mmu-miR-133a-3p, meanwhile GCH1 is the potential target of mmu-miR-1a-3p and mmu-miR-133a-3p. mmu-miR-133a-3p alleviated the production of the proinflammatory cytokines IL-1β and IL-6 induced by LPS, indicating that mmu-miR-133a-3p may have a negative regulatory effect on microglial activation in NP.
