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View full-text article in PMC

. 2021 Sep 2;118(36):e2100657118. doi: 10.1073/pnas.2100657118

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Fig. 1. — Domain arrangement of DcpG and sequence alignments with GCS globin domains and active GGDEF-EAL proteins. (A) Monomer domain arrangement of DcpG globin, GGDEF, and EAL domains. (B) Globin domain alignments with DcpG (H3SIC7), HemAt-Bs (O07621), EcDosC (P0AA89), PccGCS (C6D9C2), and BpeGreg (Q7VTL8). (a) Conserved distal tyrosine; (b) conserved proximal histidine. (C) GGDEF-EAL domain alignments with DcpG (H3SIC7), DcpA (P9WM13), AvHaCE (B9JYX6), BphG1 (Q3IUZ1), and SwDGC (B1KIH5). (a) GGDEF active site; (b) EAL active site; and (c) DDFGTG sequence essential for PDE activity.