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. 2021 Aug 31;118(36):e2105951118. doi: 10.1073/pnas.2105951118

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Fig. 5. — PGC-1α condensates compartmentalize active transcription. (A and B) Images of transfected GFP-PGC-1α FL costained with DAPI, p-Pol2 (S5), and H3K27ac in C2C12 myoblasts (MB). (C and D) Images of endogenous PGC-1α costained with laminin (yellow), DAPI, and H3K27ac in mouse skeletal muscle (GAS: gastrocnemius, SOL: soleus). (E) Images of endogenous PGC-1α costained with wheat germ agglutinin (yellow) and Hoechst in human skeletal muscle (VL: vastus lateralis). (F) Model in which PGC-1α is compartmentalized within active transcriptional condensates via multivalent protein and RNA interactions at the CTD in a tissue- and context-specific manner (prepared with Biorender). Microscopy images are representative of at least three independent samples or experiments each in triplicate.