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. 2021 Sep 1;14(17):4994. doi: 10.3390/ma14174994

Table 4.

Characteristics of the discussed antibiotics.

Common Name Erythromycin Sulphamethoxazole Tetracycline Trimethoprim
CAS Number 114-07-8 723-46-6 60-54-8 738-70-5
Molecular weight 733.93 253.28 444.44 290.32
pKa a 8.88 1.6
5.7		 3.30 7.12
log Kow a 3.06 0.89 1.37 0.91
CEC b (ng L−1) - 9.8 × 107 6.7 × 107 3.3 × 106
Classification group macrolide antibiotic sulfonamides tetracyclines anisoles
Therapeutic Use/mechanism of action Antibiotic/
bacteriostatic		 Antibiotic/
bacteriostatic		 Antibiotic/
bacteriostatic		 Antibiotic/
bactericidal
Half-lives, hours 2–3.5 10 6–12 8–10
Metabolite N-desmethylerythromycin hydroxysulfamethoxazole, acetylsulfamethoxazole ulfamethoxazole N4-hydroxylamine, sulfamethoxazole N-glucuronide not metabolized demethylated 3′- and 4′-metabolite
Reference [139,140] [141,142] [143] [142,144]

a Data were adopted from other sources [145,146]; b CEC values were adopted from [147]; a pKa —dissociation constant, a log Kow —octanol−water partition coefficient, CEC—critical environmental concentration.