Table 1.
In vitro activity of the selected 1H-indoles against M. tuberculosis H37Rv and MDR strains and an evaluation of the viability of HepG2 and Vero cells.
| Compound | H37Rv (μM) | PT2 (μM) | PT12 (μM) | PT20 (μM) | CC50 a HepG2 (µM) | CC50 a Vero (µM) |
|---|---|---|---|---|---|---|
| 3h | 18.2 | 4.5 | 9.1 | 9.1 | <30 | <30 |
| 3n | 17.2 | 17.2 | 17.2 | 17.2 | <30 | <30 |
| 3r | 19.4 | 9.7 | 19.4 | 19.4 | >30 | >30 |
| 3t | 8.4 | 8.4 | 8.4 | 8.4 | <30 | <30 |
| INH | 2.3 | 291.7 | 36.4 | 145.8 | - | - |
a Concentration that inhibits 50% of cellular viability determined by MTT and Neutral Red assays. INH, Isoniazid.