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CBC modestly inhibits CB1 signaling in autaptic hippocampal neurons, while CBDA and CBDVA are without effect. (A) CBC, (C) CBDA, and (E) CBDVA have no direct effect on EPSCs. (B) CBC modestly inhibits maximal DSE. (D,F) CBDA and CBDV do not have a significant effect on DSE-mediated inhibition of EPSCs. *, p < 0.05, paired t-test for 10 s inhibition, drug vs. baseline.
