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. 2021 Sep 2;26(17):5352. doi: 10.3390/molecules26175352

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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THCV potently inhibits presynaptic CB1 responses in autaptic neurons. (A) THCV (1 μM) has no direct effect on EPSCs. (B) THCV concentration-dependently reduces DSE inhibition of EPSCs, with significant effects even at 100 pM. *, p < 0.05, ***, p < 0.005 one-way ANOVA with Dunnett’s post hoc vs. control. (C) Sample DSE responses before and after treatment with 1 μM THCV. (D) A Schild analysis shows that the Schild slope is less than 1. (E) Sample time course showing reversal of 2-AG inhibition by THCV (100 nM). (F) Summarized data showing that THCV reverses 2-AG action. **, p < 0.01 by paired t-test. (G,H) Sample time courses showing that baclofen (25 μM) responses are similar with and without pre-treatment with THCV (100 nM). (I) Summarized data for baclofen/THCV vs. baclofen alone. p > 0.05 unpaired t-test.