Table 1.

Phytocannabinoid responses in autaptic hippocampal neurons. Values for EPSC inhibition in response to longest depolarization (10 s) for baseline and given phytocannabinoid. Paired t-test was used to compare maximal inhibition at 10 s depolarization vs. baseline in a given cell. Effective dose 50 (ED50, with 95% confidence interval) for depolarization-response curves indicating duration of depolarization that gave a 50% maximal response for the phytocannabinoids tested. None of the phytocannabinoids significantly altered the ED50.

	Inhibition at 10 s Depolarization				ED50 (95% CI)
	Concentration	Control	Drug	Significant	p Value	Control	Drug
CBC	1 μM	0.48 ± 0.06	0.68 ± 0.08	Yes	0.01	1.58 s (0.78–3.18)	3.90 s (1.40–10.87)
CBDA	1 μM	0.47 ± 0.09	0.58 ± 0.10	No	0.11	1.72 s (0.84–3.54)	3.82 s (1.29–11.32)
CBDVA	1 μM	0.27 ± 0.04	0.32 ± 0.05	No	0.24	2.23 s (1.54–3.22)	3.10 s (1.93–4.99)
CBDV	100 nM	0.37 ± 0.05	0.44 ± 0.08	No	0.17	1.78 s (1.19–2.66)	6.05 s (2.32–15.72)
	1 μM	0.49 ± 0.07	0.85 ± 0.05	Yes	0.0013	1.78 s (1.19–2.66)	0.97 s (0.18–5.19)
THCV	100 nM	0.39 ± 0.04	0.88 ± 0.04	Yes	0.0018	1.84 s (1.20–2.82)	ambiguous