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Schematic representation of the pathway induced by AURK and PLK. Both PLK and AURK phosphorylates CDC25 (cell cycle division 25), allowing CDK (cyclin-dependant kinase)/Cyclin B complex activation and thus permitting transition of the cell from the G2 phase to the M phase (mitotic entry). PLK facilitates this process by inhibiting the CDK inhibitor Wee1. Inactivation of PLK or AURK shows a marked delay in both CDK activation and mitotic entry.
