Table 2.

AK inhibition studies of N-trisubstituted pyrimidines.

Compounds	R1	IC50 (µM)
		AURKA	AURKB
38a	3,4-diOMe	0.038	0.452
38b	3,4-methylenedioxy	0.020	0.091
38c	3-OMe and 4-COOMe	0.067	0.442
38d	2,3,4-triOMe	0.094	0.188
38e	3,4-diCl	0.033	0.050
38f	3-F	0.025	0.102
38g	4-F	0.023	0.0751
38h	3,4-diF	0.017	0.0892
38i	3-F and 4-Cl	0.031	0.101
38j	3-Cl and 4-F	0.0071	0.0257
38k	3-F and 4- COOMe	0.035	0.145